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New Combination Therapy Shows Promise for Advanced Urinary Tract Cancer

New Combination Therapy Shows Promise for Advanced Urinary Tract Cancer

What Did the Research Discover? Researchers conducted a phase 3 clinical trial to evaluate whether adding nivolumab, an immune therapy, to the standard chemotherapy drugs gemcitabine and cisplatin would improve survival for patients with advanced urothelial carcinoma (a type of bladder cancer). The study included 608 patients with unresectable or metastatic...

New Discovery Could Lead to Better Treatments for Rheumatoid Arthritis

New Discovery Could Lead to Better Treatments for Rheumatoid Arthritis

What did the research discover? Researchers created a detailed map of the cells in the synovial tissue of people with rheumatoid arthritis (RA) by studying over 314,000 cells from 79 donors. They found six different types of cell patterns, called cell-type abundance phenotypes (CTAPs), which show various immune cell compositions in the inflamed joint tissue. These...

New Hope for Alzheimer’s: Tackling Protein Clumps and Aging with Mitochondria Boosters

New Hope for Alzheimer’s: Tackling Protein Clumps and Aging with Mitochondria Boosters

What did the research discover? This study explored how amyloid beta (Aβ), a protein linked to Alzheimer’s disease (AD), accelerates the process of protein insolubility that naturally occurs with aging. Protein insolubility happens when proteins clump together and lose their normal function, a hallmark of neurodegenerative diseases like Alzheimer’s, Parkinson’s, and...