What Did the Research Discover? This study examined whether adding pembrolizumab (Keytruda), an immune checkpoint inhibitor, to standard chemotherapy before surgery could improve outcomes for patients with early-stage triple-negative breast cancer (TNBC). In this large phase 3 trial, 1,174 patients with stage II or III TNBC were randomly assigned to receive either:...
What did the research discover? Researchers studied how activating a specific protein called Nrf2 could help the immune cells in the lungs, called alveolar macrophages, fight bacterial infections in chronic obstructive pulmonary disease (COPD). COPD makes it harder for these immune cells to remove harmful bacteria, leading to frequent lung infections and worsening...
What did the research discover? Researchers created a detailed map of the cells in the synovial tissue of people with rheumatoid arthritis (RA) by studying over 314,000 cells from 79 donors. They found six different types of cell patterns, called cell-type abundance phenotypes (CTAPs), which show various immune cell compositions in the inflamed joint tissue. These...
What Did the Research Discover? Gastric and gastroesophageal junction (G/GEJ) cancers are among the deadliest cancers, and while immunotherapy has become a standard treatment for advanced cases, its role in earlier-stage disease is not well understood. The PANDA trial investigated whether neoadjuvant (before surgery) immunotherapy combined with chemotherapy could...
For Immediate Release: February 28, 2025 Today, the U.S. Food and Drug Administration is providing an at-a-glance summary of news from around the agency:On Thursday, the FDA approved Odactra to include use in individuals 5 through 11 years of age to treat house dust mite induced nasal inflammation (allergic rhinitis), with or without eye inflammation...
What Did the Research Discover? Researchers studied retinitis pigmentosa (RP), an inherited eye disease that causes vision loss due to the death of light-sensitive cells in the retina. RP affects about 1 in 5,000 people worldwide, leading to symptoms like night blindness and tunnel vision. The condition is caused by genetic mutations, and more than 90 genes have...