Weight Loss That Preserves Muscle: Bimagrumab Plus Semaglutide

Mar 20, 2026

What if weight loss didn’t have to mean losing muscle? A new early research phase 2 clinical trial published in Nature Medicine tested a powerful idea: combine the currently available drug semaglutide, a GLP-1 weight-loss medication, with a second drug called bimagrumab, which is still experimental and currently not FDA approved, to see if patients could lose more fat while keeping more muscle. The results suggest this combination could change how we think about obesity treatment.

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