What did the research discover? Researchers explored quantitative imaging techniques that assess the biochemical composition of articular cartilage, offering early detection of osteoarthritis (OA) and new pathways for disease-modifying treatments. Traditional imaging methods like X-rays and standard MRIs fail to detect early-stage OA, while newer imaging techniques...
What did the research discover? Researchers examined biosimilar drugs as a cost-effective alternative to biologic disease-modifying anti-rheumatic drugs (DMARDs) for rheumatoid arthritis (RA). Biosimilars of adalimumab, etanercept, infliximab, and rituximab have been approved in the U.S. and Europe, offering comparable safety and effectiveness to their reference...
What did the research discover? This study tested whether methotrexate, a drug used to treat rheumatoid arthritis, could help reduce knee pain and stiffness in people with knee osteoarthritis (KOA). Researchers conducted a randomized, double-blind, placebo-controlled trial across 15 clinics in the United Kingdom, including 207 participants with moderate to severe...
What did the research discover? Researchers created a detailed map of the cells in the synovial tissue of people with rheumatoid arthritis (RA) by studying over 314,000 cells from 79 donors. They found six different types of cell patterns, called cell-type abundance phenotypes (CTAPs), which show various immune cell compositions in the inflamed joint tissue. These...