What is Zilbrysq prescribed for?
Zilbrysq is prescribed to treat generalized myasthenia gravis in adults who are anti-acetylcholine receptor (AChR) antibody positive.
What is Zilbrysq and what does it do?
Zilbrysq, pronounced zIL-brisk, (generic name: zilucoplan) is a new medication approved by the FDA for treating adults with a condition called generalized myasthenia gravis, specifically those who test positive for anti-acetylcholine receptor antibodies.
This condition affects the communication between nerves and muscles, leading to muscle weakness and fatigue.
Zilbrysq helps to reduce these symptoms and improve muscle strength.
How does Zilbrysq work?
Zilbrysq works on a part of the immune system called the complement system, which helps the body fight off infections but can sometimes become too active.
In myasthenia gravis, this overactivity can harm muscle cells at the spots where nerves connect to muscles, disrupting muscle function.
Zilbrysq targets a specific protein in our immune system called C5. This protein is essential for fighting infections and regulating inflammation. By blocking C5, Zilbrysq prevents the formation of a harmful complex that can damage important connection points in the body.
This protection helps improve the communication between nerves and muscles, easing the symptoms of the disease.
What did the research discover?
Clinical trials of Zilbrysq demonstrated its effectiveness in reducing symptoms of myasthenia gravis.
Patients treated with Zilbrysq showed significant improvements in muscle strength and were more able to perform daily activities compared to those who received a placebo.
Specifically, 73.1% of patients treated with Zilbrysq showed a significant improvement in symptom scores, which was much higher than the 46.1% improvement rate seen in the placebo group.
What are some of the side effects?
The side effects listed are from the product manufacturer. As health scientists, we share this information to keep you informed without causing undue worry. Many side effects diminish over time, and not all patients experience them. If prescribed medication, take it as directed and consult your healthcare professional if you have any concerning side effects.
- Injection site reactions
- Upper respiratory tract infections
- Diarrhea
- Increased levels of lipase (an enzyme that could indicate pancreas issues)
- Nausea and vomiting
What are the dosage recommendations and how is it prescribed?
Zilbrysq is administered as a subcutaneous injection, which means it’s injected under the skin. The dosage depends on the patient’s body weight, with three different dosing levels based on weight ranges.
It is available in prefilled syringes and should be taken daily. Patients are advised to rotate their injection sites to avoid skin irritation.
Source:
Highlights of Prescribing Information for [Drug Name]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/216834s000lbl.pdf. Accessed 17 July 2024.
