What Are Current Prostate Cancer Treatments? Treating advanced prostate cancer often involves lowering the levels of male hormones (called androgens) in the body. This is because prostate cancer cells usually need these hormones to grow. One common treatment is called androgen deprivation therapy (ADT), which uses special medicines to stop the body from making these...
What did the research discover? Researchers explored quantitative imaging techniques that assess the biochemical composition of articular cartilage, offering early detection of osteoarthritis (OA) and new pathways for disease-modifying treatments. Traditional imaging methods like X-rays and standard MRIs fail to detect early-stage OA, while newer imaging techniques...
What Did the Research Discover? Researchers conducted a phase 3 clinical trial to evaluate whether adding nivolumab, an immune therapy, to the standard chemotherapy drugs gemcitabine and cisplatin would improve survival for patients with advanced urothelial carcinoma (a type of bladder cancer). The study included 608 patients with unresectable or metastatic...
What did the research discover? Researchers created a detailed map of the cells in the synovial tissue of people with rheumatoid arthritis (RA) by studying over 314,000 cells from 79 donors. They found six different types of cell patterns, called cell-type abundance phenotypes (CTAPs), which show various immune cell compositions in the inflamed joint tissue. These...
What did the research discover? This study explored how amyloid beta (Aβ), a protein linked to Alzheimer’s disease (AD), accelerates the process of protein insolubility that naturally occurs with aging. Protein insolubility happens when proteins clump together and lose their normal function, a hallmark of neurodegenerative diseases like Alzheimer’s, Parkinson’s, and...
What Did the Research Discover? Low back pain is a common condition that affects millions of people worldwide. Many people take pain relievers to manage their symptoms, but this study found that most medications offer little to no benefit. The research reviewed multiple studies on non-specific low back pain, which is pain without a clear cause like a fracture or...