Hormone receptor-positive, HER2-negative breast cancer is the most common subtype of breast cancer. While treatments have improved significantly over the years, many patients eventually develop resistance to standard therapies, allowing cancer to continue growing despite treatment.
Researchers have increasingly focused on a pathway known as PI3K/AKT/mTOR/PTEN, which plays a critical role in cancer growth and survival. New therapies targeting this pathway are creating additional treatment options and helping move breast cancer care toward a more personalized future.





